Note: This method often fails on M1/M2/M3 Macs due to the shift to ARM architecture. Final Verdict
Get the official .zip or .exe from a reputable source like the BioEdit archive. Install Wine: Download and install WineHQ for macOS. bioedit download mac
Most researchers have moved away from trying to "force" BioEdit onto Mac because several native programs do the job better and faster. 1. Jalview (Free & Open Source) Note: This method often fails on M1/M2/M3 Macs