The game engine often conflicts with modern USB peripherals (keyboards/mice with extra macro keys). Right-click the Start Menu and open . Expand Human Interface Devices .
Open Notepad and paste the following: start /affinity F prototype2.exe (use F for 4 cores or FF for 8).
Prototype 2 remains a cult classic, but its modern PC port is notoriously unstable, especially when running on cracked versions or high-core CPUs. Common issues include immediate crashes at startup, blank screens, or crashing at the "Radical" logo.
Save the file as launch.bat in your main Prototype 2 installation folder. Run this .bat file to start the game. Launch the game.
Quickly Alt+Tab out, open , and go to the Details tab.
Right-click prototype2.exe , select , and uncheck all but the first 4–8 cores (CPU 0 to CPU 3). 2. Disable HID-Compliant Devices
The most common cause of Prototype 2 crashing is modern CPUs having too many cores (anything over 4-8 cores can cause instability).